Components of the extracellular matrix (ECM), the network of molecules that gives tissues their structure, are dysregulated in skin cells from people with vascular Ehlers-Danlos syndrome (vEDS), making it a possible target for therapeutic intervention, a recent study suggests. The ECM took on properties…
Abnormally high sensitivity of a type of sensory nerve fibers is behind the heightened pain responses to harmless light touch that were observed in a mouse model of classical-like Ehlers-Danlos syndrome (clEDS), a study shows. This abnormal pain sensation, called mechanical allodynia, is a main symptom of neuropathic pain…
A 23-year-old man in Greece was diagnosed with vascular Ehlers-Danlos syndrome (vEDS) about two years after his symptoms of recurrent bowel ruptures had started, according to a recent case report. While gastrointestinal involvement as the first sign of EDS has been reported, the rarity of the disease and its…
Stress in a cell compartment called the endoplasmic reticulum (ER) may cause irregularities in collagen fibrils that underlie the serious blood vessel-related symptoms of vascular Ehlers-Danlos syndrome (vEDS), according to a recent study. Patients who had more irregular collagen fibrils — major structural units of cells — tended to…
A nine-week multidisciplinary rehabilitation program was associated with improved exercise capacity, reduced fatigue, better balance, and greater life quality for people with hypermobile Ehlers-Danlos syndrome (hEDS) in a small study. Many of these benefits — and new ones — were evident six weeks and six months after the rehab…
Chronic pain was prevalent among people with classical Ehlers-Danlos syndrome (cEDS), strongly affecting life quality and emotional health, according to a recent study. cEDS patients also exhibited abnormal sensory perceptions and heightened pain responses compared with healthy people. The authors, who touted the study as the first to systematically…
A pre-implantation genetic diagnosis (PGD), used for identifying genetic abnormalities in embryos during in vitro fertilization (IVF), may help women with vascular Ehlers-Danlos syndrome (vEDS) who want children, a recent case report shows. A woman with vEDS successfully used PGD to have two biological children via surrogacy. Neither were…
Two cases of vascular Ehlers-Danlos syndrome (vEDS) were diagnosed during the treatment of severe eye-related problems and later found to be vEDS-associated complications, according to a recent report from Romania. While these complications were considered life-threatening for the young adults, prompt identification of their underlying cause enabled both patients…
Treatment of kidney stones can be safely done in people with Ehlers-Danlos syndrome (EDS) so long as certain modifications are made, a new case report from Japan highlights. A woman in her 30s with EDS, experiencing abdominal pain, was successfully treated after clinicians took into account her physical status —…
A two-week virtual mindfulness program led to quality of life improvements for people with hypermobile Ehlers-Danlos syndrome (hEDS) and hypermobility spectrum disorder (HSD), according to a recent pilot study. Patients reported benefits of the exercise included increased bodily awareness and reduced pain intensity, but participants noted a need for…
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