Vascular Ehlers-Danlos syndrome (vEDS) does not appear to increase the risk of life-threatening complications during pregnancy and delivery, according to a study in the Netherlands that looked at data from 121 pregnancies. However, about 1 in 5 of those pregnancies ended in miscarriage, a rate about twice as high…
People with hypermobile Ehlers-Danlos syndrome (EDS) often have abnormalities such as small gaps in the upper part of their spine and may hold their heads differently than individuals without the disorder, according to a study that suggests these differences could help with diagnosis and treatment. The study, “Head…
Including the experiences and needs of people with hypermobile Ehlers-Danlos syndrome (hEDS) or generalized hypermobility spectrum disorder (HSD) in treatment planning could lead to better care, and this could translate into better quality of life for these patients, the findings of a new U.S. survey study suggest. “The current…
Zevra Therapeutics has been enrolling and dosing new patients in a Phase 3 clinical trial testing celiprolol, a beta blocker being developed for people with vascular Ehlers-Danlos syndrome (vEDS) caused by mutations in the COL3A1 gene. The trial, dubbed DiSCOVER (NCT05432466), is assessing how well celiprolol works…
A fragment of fibronectin, a protein that assists in wound healing, appears to be found only in the blood of adults with hypermobile Ehlers–Danlos syndrome (hEDS) or hypermobility spectrum disorder (HSD), a study found, suggesting it as a biomarker for diagnosis. Because the fragment could not be detected in…
About every third child with Ehlers-Danlos syndrome (EDS) and every fourth with generalized joint hypermobility at a clinic in Canada had one or more bone fractures, but none had occurred in the first year of life, a study finds. Most fractures were in the limbs as the result of…
An altered breathing pattern in hypermobile Ehlers–Danlos syndrome (hEDS) may be linked to difficulty sensing how much air fills the lungs with each breath and in controlling ventilation, especially when engaging in a cognitive task, a study suggests. The study, “Impairment of lung volume perception and breathing control…
Most people with hypermobile Ehlers-Danlos syndrome (hEDS) or hypermobility spectrum disorder (HSD) carry genetic variations that affect the amount of folate available in their blood, according to a study. These findings support earlier work suggesting changes in how the body processes folate, also known as vitamin B9, may…
A man with vascular Ehlers-Danlos syndrome (vEDS) had a ruptured splenic artery, a blood vessel that supplies the spleen, days after surgery for a perforated bowel, leading researchers in Japan to call for careful monitoring after surgery. “Surgeons should cooperate with physicians and interventional radiologists to perform surgery in…
Most people with hypermobile Ehlers-Danlos syndrome (hEDS) or hypermobility spectrum disorder (HSD) have signs of functional neurological disorder, where there’s a problem with the functioning of the nervous system rather than a structural issue, a study has found. Recognizing those signs could help guide appropriate care for hEDS/HSD patients…
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