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For people with hypermobile Ehlers-Danlos syndrome (hEDS), intense pain in several body regions correlates with symptoms of depression and pain-related anxiety, a study reports. Depressive symptoms were associated most strongly with pain intensity in the lower extremities and in the abdomen. “This is the first study on patients with…

People with vascular Ehlers-Danlos syndrome (vEDS) more commonly experience artery problems than people with other disorders that are also marked by weakened blood vessels, a new study reports. The findings could help guide more personalized care and monitoring based on each individual’s condition, researchers said. “Tailored surveillance and management…

People with hypermobile Ehlers-Danlos syndrome (hEDS) show signs of dysfunction in small nerve fibers, those that detect pain and temperature and regulate automatic body functions such as heart rate and blood pressure, according to a small study. A loss of small nerve fiber function was more pronounced in hEDS…

Although people with hypermobile Ehlers-Danlos syndrome (hEDS) may not have many measurable cognitive deficits, they are more likely to experience subjective cognitive challenges and difficulty participating in social activities than their peers without the disorder, a study reports. “We speculate that the cognitive difficulties noted by many of the…

Abnormally arranged collagen fibrils, the protein building blocks of connective tissue, in the colon may help explain gastrointestinal problems in people with the rare musculocontractural form of Ehlers-Danlos syndrome (EDS), a mouse study suggested. Researchers noted that the defective collagen assembly seen in the colon of these mice is…

People with Ehlers-Danlos syndrome (EDS) and hypermobile joints generally have similar or slightly worse outcomes after surgery for shoulder, knee, and hip joint instability, compared with those without hypermobility, according to a review study. However, patients with hypermobility conditions (when joints move past the normal range of motion) have…

A national program at the University of Virginia (UVA) will provide comprehensive support for connective tissue disorders such as Ehlers-Danlos syndrome (EDS), which are generally characterized by hypermobile joints. With a targeted opening date for late this year or early 2026, the program will include multidisciplinary specialists to provide…

An unusual mutation in the PLOD1 gene caused kyphoscoliotic Ehlers-Danlos syndrome (kEDS) type 1 in a 7-year-old boy, a case study reported. Instead of a skin biopsy to investigate the clinical effect of this mutation, researchers used whole blood samples because PLOD1, unlike the genes that cause other types…

Mental health and sleep problems are prevalent in young people with hypermobile Ehlers-Danlos syndrome (hEDS) and have a negative impact oon their quality of life, a study suggests. Patient-reported anxiety and pain were the symptoms most closely associated with life quality impacts in a group of children and young…

Researchers cited a need for increased awareness of Ehlers-Danlos syndrome (EDS) as a risk factor for chronic pancreatitis in a recent case report. In a rare occurrence, a woman who had chronic pancreatic damage from a previous bout of acute pancreatitis experienced a new symptom attack without an obvious…